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Data from Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion

Posted on 2024-06-11 - 14:20
Abstract

Hemangiosarcoma and angiosarcoma are soft-tissue sarcomas of blood vessel–forming cells in dogs and humans, respectively. These vasoformative sarcomas are aggressive and highly metastatic, with disorganized, irregular blood-filled vascular spaces. Our objective was to define molecular programs which support the niche that enables progression of canine hemangiosarcoma and human angiosarcoma. Dog-in-mouse hemangiosarcoma xenografts recapitulated the vasoformative and highly angiogenic morphology and molecular characteristics of primary tumors. Blood vessels in the tumors were complex and disorganized, and they were lined by both donor and host cells. In a series of xenografts, we observed that the transplanted hemangiosarcoma cells created exuberant myeloid hyperplasia and gave rise to lymphoproliferative tumors of mouse origin. Our functional analyses indicate that hemangiosarcoma cells generate a microenvironment that supports expansion and differentiation of hematopoietic progenitor populations. Furthermore, gene expression profiling data revealed hemangiosarcoma cells expressed a repertoire of hematopoietic cytokines capable of regulating the surrounding stromal cells. We conclude that canine hemangiosarcomas, and possibly human angiosarcomas, maintain molecular properties that provide hematopoietic support and facilitate stromal reactions, suggesting their potential involvement in promoting the growth of hematopoietic tumors.

Significance:

We demonstrate that hemangiosarcomas regulate molecular programs supporting hematopoietic expansion and differentiation, providing insights into their potential roles in creating a permissive stromal-immune environment for tumor progression.

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FUNDING

HHS | NIH | National Cancer Institute (NCI)

American Kennel Club Canine Health Foundation (CHF)

National Canine Cancer Foundation (NCCF)

Morris Animal Foundation (MAF)

Cancerfonden (Swedish Cancer Society)

U.S. Department of Defense (DOD)

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AUTHORS (24)

Jong Hyuk Kim
Ashley J. Schulte
Aaron L. Sarver
Donghee Lee
Mathew G. Angelos
Aric M. Frantz
Colleen L. Forster
Timothy D. O'Brien
Ingrid Cornax
M. Gerard O'Sullivan
Nuojin Cheng
Mitzi Lewellen
LeAnn Oseth
Sunil Kumar
Susan Bullman
Chandra Sekhar Pedamallu
Sagar M. Goyal
Matthew Meyerson
Troy C. Lund
Matthew Breen
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