Data from Arsenic Trioxide and the Phosphoinositide 3-Kinase/Akt Pathway in Chronic Lymphocytic Leukemia

Platanias, Leonidas C.

Data from Arsenic Trioxide and the Phosphoinositide 3-Kinase/Akt Pathway in Chronic Lymphocytic Leukemia

Posted on 2023-03-31 - 16:08

Abstract

Simultaneous targeting of the phosphoinositide 3-kinase (PI3K)/Akt pathway increases arsenic trioxide (ATO)–dependent cytotoxicity of chronic lymphocytic leukemia (CLL) cells, whereas it has no significant effects on normal lymphocytes. Combinations of ATO with small molecules that target PI3K and/or Akt may provide a novel approach for the treatment of CLL. Clin Cancer Res; 16(17); 4311–2. ©2010 AACR.

CITE THIS COLLECTION

Goussetis, Dennis J.; Platanias, Leonidas C. (2010). Data from Arsenic Trioxide and the Phosphoinositide 3-Kinase/Akt Pathway in Chronic Lymphocytic Leukemia. American Association for Cancer Research. Collection. https://doi.org/10.1158/1078-0432.c.6518736.v1

https://doi.org/10.1158/1078-0432.c.6518736.v1

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