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Figure S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8⁺ T-cell Infiltration and Survival in Squamous Cell Carcinoma

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posted on 2023-03-31, 00:11 authored by Christian H. Ottensmeier, Kate L. Perry, Elena L. Harden, Jana Stasakova, Veronika Jenei, Jason Fleming, Oliver Wood, Jeongmin Woo, Christopher H. Woelk, Gareth J. Thomas, Stephen M. Thirdborough

Figure S3. Increased expression of the CD8+ T-cell signature has a prognostic value for overall survival. (A and B) Kaplan-Meier estimates of overall survival among patients grouped according to expression of genes with the strongest membership (kME{greater than or equal to} 0.80) for M1 and M8. (C) Univariate and multivariate overall survival analysis in HNSC patients by the Cox PH model.

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ARTICLE ABSTRACT

Antibodies that block T-cell–regulatory checkpoints have recently emerged as a transformative approach to cancer treatment. However, the clinical efficacy of checkpoint blockade depends upon inherent tumor immunogenicity, with variation in infiltrating T cells contributing to differences in objective response rates. Here, we sought to understand the molecular correlates of tumor-infiltrating T lymphocytes (TIL) in squamous cell carcinoma (SCC), using a systems biologic approach to integrate publicly available omics datasets with histopathologic features. We provide evidence that links TIL abundance and therapeutic outcome to the regulation of tumor glycolysis by EGFR and HIF, both of which are attractive molecular targets for use in combination with immunotherapeutics. Cancer Res; 76(14); 4136–48. ©2016 AACR.