Video 1 from Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring

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posted on 2023-06-14, 14:20 authored by Jean Nakhle, Khattar Khattar, Tülin Özkan, Adel Boughlita, Daouda Abba Moussa, Amélie Darlix, Frédérique Lorcy, Valérie Rigau, Luc Bauchet, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Floriant Bellvert, Laurent Turchi, Thierry Virolle, Jean-Philippe Hugnot, Nicolas Buisine, Mireille Galloni, Valérie Dardalhon, Anne-Marie Rodriguez, Marie-Luce Vignais

Cocultures of red MitoTracker-labeled MSCs and green CellTracker-labeled GSCs

Funding

Ligue Contre le Cancer (French League Against Cancer)

Fondation ARC pour la Recherche sur le Cancer (ARC)

Institut National Du Cancer (INCa)

Région Occitanie Pyrénées-Méditerranée

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ARTICLE ABSTRACT

Mitochondria acquired from MSCs enhance the chemoresistance of GBMs. The discovery that they also generate metabolic vulnerability in GSCs paves the way for novel therapeutic approaches.

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Keywords

CNS Cancers Gliomas, Glioblastomas Metabolism Metabolomics Mitochondrial function Tumor Microenvironment Tumor-stromal cell interactions Small Molecule Agents Alkylating agents Drug Resistance

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CC BY

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