Supplementary Movie_4 from Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase

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posted on 2024-12-13, 11:20 authored by Lynn M. Knowles, Carolin Wolter, Stefan Linsler, Simon Müller, Steffi Urbschat, Ralf Ketter, Andreas Müller, Xiangda Zhou, Bin Qu, Sebastian Senger, Jürgen Geisel, Tim Schmidt, Hermann Eichler, Jan Pilch

U373MG cells on day 1 after embedding in fibrin

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ARTICLE ABSTRACT

High-grade gliomas are associated with intratumoral thrombosis, tumor cell necrosis, and hemorrhage. The resulting blood clot serves as an adhesive matrix for glioma cell integrins that activate FAK. Knocking down FAK with CRISPR cas9, on the other hand, is highly effective at halting GBM growth in mice.