Supplementary Movie_1 from Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase

media

posted on 2024-12-13, 11:20 authored by Lynn M. Knowles, Carolin Wolter, Stefan Linsler, Simon Müller, Steffi Urbschat, Ralf Ketter, Andreas Müller, Xiangda Zhou, Bin Qu, Sebastian Senger, Jürgen Geisel, Tim Schmidt, Hermann Eichler, Jan Pilch

U87MG cells on day 1 after embedding in fibrin

History

ARTICLE ABSTRACT

High-grade gliomas are associated with intratumoral thrombosis, tumor cell necrosis, and hemorrhage. The resulting blood clot serves as an adhesive matrix for glioma cell integrins that activate FAK. Knocking down FAK with CRISPR cas9, on the other hand, is highly effective at halting GBM growth in mice.