Movie S4 from Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer

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posted on 2023-04-04, 02:02 authored by John B. Tucker, Sarah C. Bonema, Rebeca García-Varela, Ryan A. Denu, Yang Hu, Stephanie M. McGregor, Mark E. Burkard, Beth A. Weaver

Chromosome bridge

Funding

HHS | NIH | National Cancer Institute (NCI)

U.S. Department of Defense (DOD)

HHS | NIH | National Institute of General Medical Sciences (NIGMS)

History

ARTICLE ABSTRACT

We surveyed the single-cell landscape of mitotic defects that generate CIN in primary and metastatic breast cancer and relevant models. Misaligned chromosomes predominate, and are less immunostimulatory than other chromosome segregation errors.