00085472can161917-sup-169027_3_unknown_upload_3987835_55m4h6.mp4 (11.07 MB)
Movie S1 from Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits
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posted on 2023-03-31, 00:43 authored by Jorge Barbazán, Lorena Alonso-Alconada, Nadia Elkhatib, Sara Geraldo, Vasily Gurchenkov, Alexandros Glentis, Guillaume van Niel, Roberta Palmulli, Beatriz Fernández, Patricia Viaño, Tomas Garcia-Caballero, Rafael López-López, Miguel Abal, Danijela Matic VignjevicMovie S1 from Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits
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ARTICLE ABSTRACT
The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bearing primary tumors and are also present in vessels from human livers affected with metastases. Cancer cells attached to endothelial fibronectin deposits via talin1, a major component of focal adhesions. Talin1 depletion impaired cancer cell adhesion to the endothelium and transendothelial migration, resulting in reduced liver metastasis formation in vivo. Talin1 expression levels in patient CTC's correlated with prognosis and therapy response. Together, our findings uncover a new mechanism for liver metastasis formation involving an active contribution of hepatic vascular fibronectin and talin1 in cancer cells. Cancer Res; 77(13); 3431–41. ©2017 AACR.Usage metrics
Keywords
CarcinogenesisTumor initiation and promotionCell SignalingCell adhesionCell-cell interactionsGastrointestinal CancersColorectal cancerProgression, Invasion & MetastasisCell adhesion and extracellular matrixMetastasisMigration and invasionTumor progressionTumor MicroenvironmentTumor-stromal cell interactions
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