American Association for Cancer Research
crc-22-0300-s09.pdf (166.45 kB)

Table S4 from Humanized Patient-derived Xenograft Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity

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journal contribution
posted on 2023-04-04, 02:20 authored by Mara P. Steinkamp, Irina Lagutina, Kathryn J. Brayer, Fred Schultz, Danielle Burke, Vernon S. Pankratz, Sarah F. Adams, Laurie G. Hudson, Scott A. Ness, Angela Wandinger-Ness

Human cytokines with significantly higher levels in PDX ascites samples compared to plasma samples


HHS | NIH | National Cancer Institute (NCI)

UNM | School of Medicine, University of New Mexico (UNM SOM)



huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.