Table S2 from Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy

Lee, Te-An; Tsai, En-Yun; Liu, Shou-Hou; Hsu Hung, Shih-Duo; Chang, Shing-Jyh; Chao, Chi-Hong; Lai, Yun-Ju; Yamaguchi, Hirohito; Li, Chia-Wei

doi:10.1158/0008-5472.25415385.v1

Table S2 from Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy

https://doi.org/10.1158/0008-5472.25415385

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posted on 2024-03-15, 07:20 authored by Te-An Lee, En-Yun Tsai, Shou-Hou Liu, Shih-Duo Hsu Hung, Shing-Jyh Chang, Chi-Hong Chao, Yun-Ju Lai, Hirohito Yamaguchi, Chia-Wei Li

<p>Ongoing clinical trial of phosphorylation-associated small molecule drugs and anti-PD-1/PD-L1 combination</p>

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DOI - Is supplement to Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy

ARTICLE ABSTRACT

Activation of effector T cells leads to upregulation of PD-1, which can inhibit T-cell activity following engagement with its ligand PD-L1. Post-translational modifications (PTM), including glycosylation, phosphorylation, ubiquitination, and palmitoylation, play a significant role in regulating PD-1 protein stability, localization, and interprotein interactions. Targeting PTM of PD-1 in T cells has emerged as a potential strategy to overcome PD-1–mediated immunosuppression in cancer and enhances antitumor immunity. The regulatory signaling pathways that induce PTM of PD-1 can be suppressed with small-molecule inhibitors, and mAbs can directly target PD-1 PTMs. Preliminary outcomes from exploratory studies suggest that focusing on the PTM of PD-1 has strong therapeutic potential and can enhance the response to anti-PD-1.

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Gene Regulation Posttranscriptional and translational control Immunotherapy Biomarkers for immunotherapy Checkpoint blockade

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Table S2 from Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy

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