Table S2 from Discovery of Human-Similar Gene Fusions in Canine Cancers

Ulvé, Ronan; Rault, Mélanie; Bahin, Mathieu; Lagoutte, Laetitia; Abadie, Jérôme; De Brito, Clotilde; Coindre, Jean-Michel; Botherel, Nadine; Rousseau, Audrey; Wucher, Valentin; Cadieu, Edouard; Thieblemont, Catherine; Hitte, Christophe; Cornevin, Laurence; Cabillic, Florian; Bachelot, Laura; Gilot, David; Hennuy, Benoit; Guillaudeux, Thierry; Le Goff, Arnaud; Derrien, Thomas; Hédan, Benoît; André, Catherine

doi:10.1158/0008-5472.22418496.v1

00085472can162691-sup-171198_4_supp_4221878_ffvkf5.docx (113.54 kB)

Table S2 from Discovery of Human-Similar Gene Fusions in Canine Cancers

journal contribution

posted on 2023-03-31, 01:42 authored by Ronan Ulvé, Mélanie Rault, Mathieu Bahin, Laetitia Lagoutte, Jérôme Abadie, Clotilde De Brito, Jean-Michel Coindre, Nadine Botherel, Audrey Rousseau, Valentin Wucher, Edouard Cadieu, Catherine Thieblemont, Christophe Hitte, Laurence Cornevin, Florian Cabillic, Laura Bachelot, David Gilot, Benoit Hennuy, Thierry Guillaudeux, Arnaud Le Goff, Thomas Derrien, Benoît Hédan, Catherine André

Primers used for validation of the canine gene fusions.

Funding

CNRS

INCa

PIA

Innovate UK

Find out more...

History

ARTICLE ABSTRACT

Canine cancers represent a tremendous natural resource due to their incidence and striking similarities to human cancers, sharing similar clinical and pathologic features as well as oncogenic events, including identical somatic mutations. Considering the importance of gene fusions as driver alterations, we explored their relevance in canine cancers. We focused on three distinct human-comparable canine cancers representing different tissues and embryonic origins. Through RNA-Seq, we discovered similar gene fusions as those found in their human counterparts: IGK-CCND3 in B-cell lymphoma, MPB-BRAF in glioma, and COL3A1-PDGFB in dermatofibrosarcoma protuberans-like. We showed not only similar partner genes but also identical breakpoints leading to oncogene overexpression. This study demonstrates similar gene fusion partners and mechanisms in human–dog corresponding tumors and allows for selection of targeted therapies in preclinical and clinical trials with pet dogs prior to human trials, within the framework of personalized medicine. Cancer Res; 77(21); 5721–7. ©2017 AACR.

Usage metrics

Keywords

Cns Cancers Dna Damage And Repair Chromosomal translocations Hematological Cancers Leukemias Preclinical Models Animal models of cancer Sarcomas Soft-tissue sarcoma

Licence

CC BY

Exports

RefWorks

BibTeX

Ref. manager

Endnote

DataCite

NLM

DC

Table S2 from Discovery of Human-Similar Gene Fusions in Canine Cancers

Funding

CNRS

INCa

PIA

History

ARTICLE ABSTRACT

Usage metrics

Categories

Keywords

Licence

Exports