American Association for Cancer Research
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Table S1 from Inherited Genetic Variants Associated with Occurrence of Multiple Primary Melanoma

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posted on 2023-03-31, 13:46 authored by David C. Gibbs, Irene Orlow, Peter A. Kanetsky, Li Luo, Anne Kricker, Bruce K. Armstrong, Hoda Anton-Culver, Stephen B. Gruber, Loraine D. Marrett, Richard P. Gallagher, Roberto Zanetti, Stefano Rosso, Terence Dwyer, Ajay Sharma, Emily La Pilla, Lynn From, Klaus J. Busam, Anne E. Cust, David W. Ollila, Colin B. Begg, Marianne Berwick, Nancy E. Thomas

Table S1. Demographic and phenotypic characteristics among muliple and single primary melanoma patients in the GEM study



Recent studies, including genome-wide association studies, have identified several putative low-penetrance susceptibility loci for melanoma. We sought to determine their generalizability to genetic predisposition for multiple primary melanoma in the international population-based Genes, Environment, and Melanoma (GEM) Study. GEM is a case–control study of 1,206 incident cases of multiple primary melanoma and 2,469 incident first primary melanoma participants as the control group. We investigated the odds of developing multiple primary melanoma for 47 SNPs from 21 distinct genetic regions previously reported to be associated with melanoma. ORs and 95% confidence intervals were determined using logistic regression models adjusted for baseline features (age, sex, age by sex interaction, and study center). We investigated univariable models and built multivariable models to assess independent effects of SNPs. Eleven SNPs in 6 gene neighborhoods (TERT/CLPTM1L, TYRP1, MTAP, TYR, NCOA6, and MX2) and a PARP1 haplotype were associated with multiple primary melanoma. In a multivariable model that included only the most statistically significant findings from univariable modeling and adjusted for pigmentary phenotype, back nevi, and baseline features, we found TERT/CLPTM1L rs401681 (P = 0.004), TYRP1 rs2733832 (P = 0.006), MTAP rs1335510 (P = 0.0005), TYR rs10830253 (P = 0.003), and MX2 rs45430 (P = 0.008) to be significantly associated with multiple primary melanoma, while NCOA6 rs4911442 approached significance (P = 0.06). The GEM Study provides additional evidence for the relevance of these genetic regions to melanoma risk and estimates the magnitude of the observed genetic effect on development of subsequent primary melanoma. Cancer Epidemiol Biomarkers Prev; 24(6); 992–7. ©2015 AACR.

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