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Supplementary tables 1-4 and figures 1-4 from NHANES 2009–2012 Findings: Association of Sexual Behaviors with Higher Prevalence of Oral Oncogenic Human Papillomavirus Infections in U.S. Men

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posted on 2023-03-30, 23:06 authored by Anil K. Chaturvedi, Barry I. Graubard, Tatevik Broutian, Robert K.L. Pickard, Zhen-yue Tong, Weihong Xiao, Lisa Kahle, Maura L. Gillison
<p>Supplementary tables 1-4 and figures 1-4: Table 1: Comparison of non-participants/non-responders versus participants/responders for the oral HPV protocol of NHANES 2009-2012. Table 2: Comparison of oral HPV prevalence between NHANES 2009-2010 and NHANES 2011-2012. Table 3: Prevalence of oral oncogenic HPV infection and unadjusted prevalence differences by demographic and behavioral characteristics among men and women in the U.S., NHANES 2009-2012. Table 4: Adjusted associations of demographic and behavioral factors with HPV prevalence for 12 oncogenic HPV types among men and women in the U.S. population, NHANES 2009-2012. Figure 1: Adjusted association of age with oral oncogenic HPV prevalence among men and women in the U.S., NHANES 2009-2012. Figure 2: Prevalence of oral oncogenic HPV among men and women in the U.S. (NHANES 2009-2012) using a revised classification for oncogenic types. Figure 3: Burden of 12 oral oncogenic HPV infection among men in the U.S. population, NHANES 2009-2012. Figure 4: Burden of 12 oral oncogenic HPV infection among women in the U.S. population, NHANES 2009-2012.</p>

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    DOI - Is supplement to NHANES 2009–2012 Findings: Association of Sexual Behaviors with Higher Prevalence of Oral Oncogenic Human Papillomavirus Infections in U.S. Men

ARTICLE ABSTRACT

The incidence of human papillomavirus (HPV)–positive oropharyngeal cancers is higher and increasing more rapidly among men than women in the United States for unknown reasons. We compared the epidemiology of oral oncogenic HPV infection between men and women ages 14 to 69 years (N = 9,480) within the U.S. National Health and Nutritional Examination Surveys (NHANES) 2009–2012. HPV presence was detected in oral DNA by PCR. Analyses were stratified by gender and used NHANES sample weights. Oral oncogenic HPV prevalence was higher among men than women (6.6% vs. 1.5%, P < 0.001), corresponding to 7.07 million men versus 1.54 million women with prevalent infection at any point in time during 2009–2012. Prevalence increased significantly with age, current smoking, and lifetime number of sexual partners for both genders (adjusted Ptrend < 0.02). However, men had more partners than women (mean = 18 vs. 7, P < 0.001). Although oncogenic HPV prevalence was similar for men and women with 0 to 1 lifetime partners, the male–female difference in prevalence significantly increased with number of lifetime partners (adjusted prevalence differences for none, 1, 2–5, 6–10, 11–20, and 20+ partners = 1.0%, 0.5%, 3.0%, 5.7%, 4.6%, and 9.3%, respectively). Importantly, the per-sexual partner increase in prevalence was significantly stronger among men than among women (adjusted synergy index = 3.3; 95% confidence interval, 1.1–9.7), and this increase plateaued at 25 lifetime partners among men versus10 partners among women. Our data suggest that the higher burden of oral oncogenic HPV infections and HPV-positive oropharyngeal cancers among men than women arises in part from higher number of lifetime sexual partners and stronger associations with sexual behaviors among men. Cancer Res; 75(12); 2468–77. ©2015 AACR.

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    Cancer Research

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    Environmental Risk FactorsViral infectionHead, Neck & Oral Cancers

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