Supplementary Tables S1-S11 and Figure S1 from Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047

Shiels, Meredith S.; Lipkowitz, Stanley; Campos, Nicole G.; Schiffman, Mark; Schiller, John T.; Freedman, Neal D.; Berrington de González, Amy

doi:10.1158/2159-8290.22677667.v1

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Supplementary Tables S1-S11 and Figure S1 from Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047

journal contribution

posted on 2023-04-21, 21:20 authored by Meredith S. Shiels, Stanley Lipkowitz, Nicole G. Campos, Mark Schiffman, John T. Schiller, Neal D. Freedman, Amy Berrington de González

Supplemental Table 1. 15 leading causes of cancer death in the U.S. in 2019. Supplemental table 2. Trends in total cancer mortality rates, incidence rates and relative survival in the U.S. Supplemental table 3. Trends in lung cancer mortality rates, incidence rates and relative survival in the U.S. Supplemental table 4. Trends in colorectal cancer mortality rates, incidence rates and relative survival in the U.S. Supplemental table 5. Trends in pancreatic cancer mortality rates, incidence rates and relative survival in the U.S. Supplemental table 6. Trends in female breast cancer mortality rates, incidence rates and relative survival in the U.S. Supplemental table 7. Trends in prostate cancer mortality rates, incidence rates and relative survival in the U.S. Supplemental table 8. Trends in liver/IHBD cancer mortality rates, incidence rates and relative survival in the U.S. Supplemental table 9. Trends in cancer mortality rates in the U.S., 2000-2019 for selected sites. Supplemental Table 10. US breast cancer incidence-based mortality*. Supplemental Table 11. U.S. breast cancer incidence-based mortality by age at death. Supplemental Figure 1. Liver cancer incidence (1992-2019), survival (2000-2019) and mortality (2000-2019 projected through 2047). This figure excludes cases of intrahepatic bile duct cancer.

History

ARTICLE ABSTRACT

On February 2, 2022, President Biden and First Lady Dr. Biden reignited the Cancer Moonshot, setting a new goal to reduce age-standardized cancer mortality rates by at least 50% over the next 25 years in the United States. We estimated trends in U.S. cancer mortality during 2000 to 2019 for all cancers and the six leading types (lung, colorectum, pancreas, breast, prostate, liver). Cancer death rates overall declined by 1.4% per year from 2000 to 2015, accelerating to 2.3% per year during 2016 to 2019, driven by strong declines in lung cancer mortality (−4.7%/year, 2014 to 2019). Recent declines in colorectal (−2.0%/year, 2010–2019) and breast cancer death rates (−1.2%/year, 2013–2019) also contributed. However, trends for other cancer types were less promising. To achieve the Moonshot goal, progress against lung, colorectal, and breast cancer deaths needs to be maintained and/or accelerated, and new strategies for prostate, liver, pancreatic, and other cancers are needed. We reviewed opportunities to prevent, detect, and treat these common cancers that could further reduce population-level cancer death rates and also reduce disparities. We reviewed opportunities to prevent, detect, and treat common cancers, and show that to achieve the Moonshot goal, progress against lung, colorectal, and breast cancer deaths needs to be maintained and/or accelerated, and new strategies for prostate, liver, pancreatic, and other cancers are needed.