Supplementary Tables 1 - 11 from Comparison of Associations of Body Mass Index, Abdominal Adiposity, and Risk of Colorectal Cancer in a Large Prospective Cohort Study

Keimling, Marlen; Renehan, Andrew G.; Behrens, Gundula; Fischer, Beate; Hollenbeck, Albert R.; Cross, Amanda J.; Leitzmann, Michael F.

doi:10.1158/1055-9965.22437129.v1

10559965epi130353-sup-epi-13-0353tab1-13.pdf (163.71 kB)

Supplementary Tables 1 - 11 from Comparison of Associations of Body Mass Index, Abdominal Adiposity, and Risk of Colorectal Cancer in a Large Prospective Cohort Study

journal contribution

posted on 2023-03-31, 13:47 authored by Marlen Keimling, Andrew G. Renehan, Gundula Behrens, Beate Fischer, Albert R. Hollenbeck, Amanda J. Cross, Michael F. Leitzmann

PDF file - 163K, Table S1: Comparison of baseline characteristics of the overall cohort including 566,401 participants and our analytic cohort including 203,177 participants in the NIH-AARP Diet and Health Study by gender.: Table S2: Correlations of anthropometric parameters in men and women in the NIH-AARP Diet and Health Study.: Table S3: Means and standard deviations of anthropometry parameters in men and women in the NIH-AARP Diet and Health Study.: Table S4: Hazard ratios and 95% confidence intervals for risk of incident rectal cancer by gender across categories of anthropometric measures in the NIH-AARP Diet and Health Study.: Table S5: Hazard ratios and 95% confidence intervals for risk of incident colon cancer across categories of anthropometric measures in women stratified by age in the NIH-AARP Diet and Health Study.: Table S6: Hazard ratios and 95% confidence intervals for risk of incident colon cancer across categories of anthropometric measures in women stratified by colonic sub-site (distal vs. proximal) in the NIH-AARP Diet and Health Study.: Table S7: Hazard ratio, 95% confidence intervals of colon cancer and Δ HR across waist circumference measures in women with current hormone replacement therapy (HRT) use in the NIH-AARP Diet and Health Study.: Table S8: Hazard ratios and 95% confidence intervals for risk of incident colon cancer across categories of anthropometric measures in women stratified by hormone replacement therapy (HRT) use in the NIH-AARP Diet and Health Study.: Table S9: Hazard ratios and 95% confidence intervals for risk of incident rectal cancer across categories of anthropometric measures in women stratified by hormone replacement therapy (HRT) use in the NIH-AARP Diet and Health Study.: Table S10: Hazard ratios and 95% confidence intervals for risk of incident rectal cancer across categories of anthropometric measures in women stratified by hormone replacement therapy (HRT) use in the NIH-AARP Diet and Health Study.: Table S11: Hazard ratios and 95% confidence intervals for risk of incident colon cancer across categories of anthropometric measures in men and women with exclusion of the first 2 years of follow-up in the NIH-AARP Diet and Health Study.

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ARTICLE ABSTRACT

Background: Increased body mass index (BMI) is an established colorectal cancer risk factor. High waist circumference or waist-hip-ratio (WHR) may better reflect an abnormal metabolic state and be more predictive of colorectal cancer risk than BMI.Methods: We examined BMI, waist circumference, WHR, and hip circumference in relation to colorectal cancer risk among 203,177 participants followed for 10 years. We derived standardized colorectal cancer risk estimates for each anthropometric parameter and compared predictive characteristics (Harrell's C-index). In women, we examined whether hormone replacement therapy (HRT) use modified the associations between anthropometric measures and colorectal cancer.Results: We ascertained 2,869 colorectal cancers. In men, increased colon cancer risks were associated with BMI [HR per SD, 1.14; 95% confidence interval (CI), 1.08–1.20], waist circumference (HR per SD, 1.17; 95% CI, 1.08–1.27), and WHR (HR per SD, 1.09; 95% CI, 1.04–1.14). In women, anthropometric variables were unrelated to colon cancer. For men and women, anthropometric variables were unrelated to rectal cancer. Compared with BMI, waist circumference and WHR did not materially influence colon cancer prediction models [C-index changes: −0.0041 and 0.0046 (men); 0.0004 and 0.0005 (women)]. In current HRT users, colon cancer was inversely or suggestively inversely associated with waist circumference (HR per SD, 0.78; 95% CI, 0.63–0.97) and WHR (HR per SD, 0.88; 95% CI, 0.76–1.01), but positively related to hip circumference (HR per SD, 1.39; 95% CI, 1.13–1.71).Conclusion: BMI, waist circumference, and WHR show comparable positive associations with colon cancer in men. Associations between anthropometric measures and colon cancer are weak or null in women, but there is some evidence for effect modification by HRT.Impact: These findings may improve our understanding of the relation of adiposity to colorectal cancer. Cancer Epidemiol Biomarkers Prev; 22(8); 1383–94. ©2013 AACR.