American Association for Cancer Research
Browse
10780432ccr060535-sup-ccr_10-15-06_ziober.pdf (169.87 kB)

Supplementary Tables 1-6 from Identification of a Gene Signature for Rapid Screening of Oral Squamous Cell Carcinoma

Download (169.87 kB)
journal contribution
posted on 2023-03-31, 16:07 authored by Amy F. Ziober, Kirtesh R. Patel, Faizan Alawi, Phyllis Gimotty, Randall S. Weber, Michael M. Feldman, Ara A. Chalian, Gregory S. Weinstein, Jennifer Hunt, Barry L. Ziober
Supplementary Tables 1-6 from Identification of a Gene Signature for Rapid Screening of Oral Squamous Cell Carcinoma

History

ARTICLE ABSTRACT

Purpose: Oral cancer is a major health problem worldwide and in the U.S. The 5-year survival rate for oral cancer has not improved significantly over the past 20 years and remains at ∼50%. Patients diagnosed at an early stage of the disease typically have an 80% chance for cure and functional outcome, however, most patients are identified when the cancer is advanced. Thus, a convenient and an accurate way to detect oral cancer early will decrease patient morbidity and mortality. The ability to noninvasively monitor oral cancer onset, progression, and treatment outcomes requires two prerequisites: identification of specific biomarkers for oral cancers as well as noninvasive access to and monitoring of these biomarkers that could be conducted at the point of care (i.e., practitioner's or dentist's office) by minimally trained personnel.Experimental Design: Here, we show that DNA microarray gene expression profiling of matched tumor and normal specimens can identify distinct anatomic site expression patterns and a highly significant gene signature distinguishing normal from oral squamous cell carcinoma (OSCC) tissue.Results: Using a supervised learning algorithm, we generated a 25-gene signature for OSCC that can classify normal and OSCC specimens. This 25-gene molecular predictor was 96% accurate on cross-validation, averaging 87% accuracy using three independent validation test sets and failing to predict non–oral tumors.Conclusion: Identification and validation of this tissue-specific 25-gene molecular predictor in this report is our first step towards developing a new, noninvasive, microfluidic-based diagnostic technology for mass screening, diagnosis, and treatment of pre-OSCC and OSCC.

Usage metrics

    Clinical Cancer Research

    Categories

    Keywords

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC