Supplementary Tables 1-5 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

Hong, Seung-Woo; Kim, Chang-Jae; Park, Won-Sang; Shin, Jae-Sik; Lee, Soon-Duck; Ko, Seong-Gyu; Jung, Sam-Il; Park, In-Chul; An, Sung-Kwan; Lee, Won-Keun; Lee, Wang-Jae; Jin, Dong-Hoon; Lee, Myeong-Sok

doi:10.1158/0008-5472.22379964.v1

Supplementary Tables 1-5 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

https://doi.org/10.1158/0008-5472.22379964

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posted on 2023-03-30, 19:03 authored by Seung-Woo Hong, Chang-Jae Kim, Won-Sang Park, Jae-Sik Shin, Soon-Duck Lee, Seong-Gyu Ko, Sam-Il Jung, In-Chul Park, Sung-Kwan An, Won-Keun Lee, Wang-Jae Lee, Dong-Hoon Jin, Myeong-Sok Lee

Supplementary Tables 1-5 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

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DOI - Is supplement to p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

ARTICLE ABSTRACT

The p34SEI-1 protein exerts oncogenic effects via regulation of the cell cycle, which occurs through a direct interaction with cyclin-dependent kinase 4. Such regulation can increase the survival of various types of tumor cells. Here, we show that the antiapoptotic function of p34SEI-1 increases tumor cell survival by protecting the X-linked inhibitor of apoptosis protein (XIAP) from degradation. Our findings show that p34SEI-1 inhibits apoptosis. This antiapoptotic effect was eliminated by the suppression of p34SEI-1 expression. We also determined that direct binding of p34SEI-1 to the BIR2 domain prevents ubiquitination of XIAP. Interestingly, p34SEI-1 expression is absent or weak in normal tissues but is strongly expressed in tissues obtained from patients with breast cancer. Furthermore, the expression levels of p34SEI-1 and XIAP seem to be coordinated in human breast cancer cell lines and tumor tissues. Thus, our findings reveal that p34SEI-1 uses a novel apoptosis-inhibiting mechanism to stabilize XIAP. [Cancer Res 2009;69(3):741–6]

Supplementary Tables 1-5 from p34<sup>SEI-1</sup> Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34<sup>SEI-1</sup> as a Novel Target for Anti–Breast Cancer Strategies

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