Supplementary Tables 1-3 from A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice

Pannellini, Tania; Iezzi, Manuela; Liberatore, Marcella; Sabatini, Federica; Iacobelli, Stefano; Rossi, Cosmo; Alberti, Saverio; Di Ilio, Carmine; Vitaglione, Paola; Fogliano, Vincenzo; Piantelli, Mauro

doi:10.1158/1940-6207.22524287.v1

19406207capr090237-sup-capr-09-0237_tables_1-3.pdf (19.88 kB)

Supplementary Tables 1-3 from A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice

journal contribution

posted on 2023-04-03, 19:22 authored by Tania Pannellini, Manuela Iezzi, Marcella Liberatore, Federica Sabatini, Stefano Iacobelli, Cosmo Rossi, Saverio Alberti, Carmine Di Ilio, Paola Vitaglione, Vincenzo Fogliano, Mauro Piantelli

Supplementary Tables 1-3 from A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice

History

ARTICLE ABSTRACT

Transgenic adenocarcinoma of the mouse prostate (TRAMP) is a model for progressive prostate cancer that mirrors the stages of the human form. In this study, the effects of a diet enriched with processed whole tomatoes on survival, tumorigenesis, and progression of prostate cancer, and the antioxidant and inflammatory status of TRAMP mice were investigated. Tomato diet significantly increased overall survival (P < 0.01), delayed progression from prostatic intraepithelial neoplasia to adenocarcinoma, and decreased the incidence of poorly differentiated carcinoma. Biochemical data disclosed an increase in serum antioxidant activity and a reduction of serum inflammation/angiogenesis biomarkers of particular importance in prostate carcinogenesis. Cancer Prev Res; 3(10); 1284–91. ©2010 AACR.