American Association for Cancer Research
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Supplementary Table S3 from Racial Differences in the Association Between Preoperative Serum Cholesterol and Prostate Cancer Recurrence: Results from the SEARCH Database

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posted on 2023-03-31, 13:41 authored by Emma H. Allott, Lauren E. Howard, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher L. Amling, Matthew R. Cooperberg, Stephen J. Freedland

Impact of race on associations between preoperative lipid levels and prostate cancer recurrence, treating non-prostate cancer deaths as a competing risk



University Cancer Research Fund of North Carolina



Background: Black men are disproportionately affected by both cardiovascular disease and prostate cancer. Epidemiologic evidence linking dyslipidemia, an established cardiovascular risk factor, and prostate cancer progression is mixed. As existing studies were conducted in predominantly non-black populations, research on black men is lacking.Methods: We identified 628 black and 1,020 non-black men who underwent radical prostatectomy and never used statins before surgery in the Shared Equal Access Regional Cancer Hospital (SEARCH) database. Median follow-up was 2.9 years. The impact of preoperative hypercholesterolemia on risk of biochemical recurrence was examined using multivariable, race-stratified proportional hazards. In secondary analysis, we examined associations with low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, overall and among men with dyslipidemia.Results: High cholesterol was associated with increased risk of recurrence in black [HRper10 mg/dL 1.06; 95% confidence interval (CI), 1.02–1.11] but not non-black men (HRper10 mg/dL 0.99; 95% CI, 0.95–1.03; Pinteraction = 0.011). Elevated triglycerides were associated with increased risk in both black and non-black men (HRper10 mg/dL 1.02; 95% CI, 1.00–1.03 and 1.02; 95% CI, 1.00–1.02, respectively; Pinteraction = 0.458). There were no significant associations between LDL or HDL and recurrence risk in either race. Associations with cholesterol, LDL, and triglycerides were similar among men with dyslipidemia, but low HDL was associated with increased risk of recurrence in black, but not non-black men with dyslipidemia (Pinteraction = 0.047).Conclusion: Elevated cholesterol was a risk factor for recurrence in black but not non-black men, whereas high triglycerides were associated with increased risk regardless of race.Impact: Significantly contrasting associations by race may provide insight into prostate cancer racial disparities. Cancer Epidemiol Biomarkers Prev; 25(3); 547–54. ©2016 AACR.

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