Supplementary Table S3 from Complex Formation and Function of Estrogen Receptor α in Transcription Requires RIP140
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posted on 2023-03-30, 22:42 authored by Meritxell Rosell, Ekaterina Nevedomskaya, Suzan Stelloo, Jaya Nautiyal, Ariel Poliandri, Jennifer H. Steel, Lodewyk F.A. Wessels, Jason S. Carroll, Malcolm G. Parker, Wilbert Zwart<p>Supplementary Table S3. Motif analyses for ERα and RIP140 binding sites.</p>
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- 1. DOI - Is supplement to Complex Formation and Function of Estrogen Receptor α in Transcription Requires RIP140
ARTICLE ABSTRACT
RIP140 is a transcriptional coregulator involved in energy homeostasis, ovulation, and mammary gland development. Although conclusive evidence is lacking, reports have implicated a role for RIP140 in breast cancer. Here, we explored the mechanistic role of RIP140 in breast cancer and its involvement in estrogen receptor α (ERα) transcriptional regulation of gene expression. Using ChIP-seq analysis, we demonstrate that RIP140 shares more than 80% of its binding sites with ERα, colocalizing with its interaction partners FOXA1, GATA3, p300, CBP, and p160 family members at H3K4me1-demarcated enhancer regions. RIP140 is required for ERα-complex formation, ERα-mediated gene expression, and ERα-dependent breast cancer cell proliferation. Genes affected following RIP140 silencing could be used to stratify tamoxifen-treated breast cancer cohorts, based on clinical outcome. Importantly, this gene signature was only effective in endocrine-treated conditions. Cumulatively, our data suggest that RIP140 plays an important role in ERα-mediated transcriptional regulation in breast cancer and response to tamoxifen treatment. Cancer Res; 74(19); 5469–79. ©2014 AACR.Usage metrics
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Cancer PreventionIdentification of new risk factorsCarcinogenesisHormonal carcinogenesisDrug MechanismsCellular responses to anticancer drugsDrug ResistanceRegulation of gene expression in drug resistanceDrug TargetsOncoprotein & tumor suppressor drug targetsEndocrine-Related CancersEndocrinologyHormone signaling and inhibitorsSteroid hormones and receptorsGene RegulationOncogenic transcription factors
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