Supplementary Table S2 from Improved Differentiation of Benign and Malignant Breast Tumors with Multiparametric 18Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Feasibility Study

Pinker, Katja; Bogner, Wolfgang; Baltzer, Pascal; Karanikas, Georgios; Magometschnigg, Heinrich; Brader, Peter; Gruber, Stephan; Bickel, Hubert; Dubsky, Peter; Bago-Horvath, Zsuzsanna; Bartsch, Rupert; Weber, Michael; Trattnig, Siegfried; Helbich, Thomas H.

doi:10.1158/1078-0432.22449299.v1

10780432ccr132810-sup-116578_1_supp_2376992_n212l6.docx (92.22 kB)

Supplementary Table S2 from Improved Differentiation of Benign and Malignant Breast Tumors with Multiparametric ¹⁸Fluorodeoxyglucose Positron Emission Tomography Magnetic Resonance Imaging: A Feasibility Study

journal contribution

posted on 2023-03-31, 17:30 authored by Katja Pinker, Wolfgang Bogner, Pascal Baltzer, Georgios Karanikas, Heinrich Magometschnigg, Peter Brader, Stephan Gruber, Hubert Bickel, Peter Dubsky, Zsuzsanna Bago-Horvath, Rupert Bartsch, Michael Weber, Siegfried Trattnig, Thomas H. Helbich

BI-RADSÂ® assessment categories.

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ARTICLE ABSTRACT

Purpose: To assess whether multiparametric 18fluorodeoxyglucose positron emission tomography magnetic resonance imaging (MRI) (MP 18FDG PET-MRI) using dynamic contrast-enhanced MRI (DCE-MRI), diffusion-weighted imaging (DWI), three-dimensional proton MR spectroscopic imaging (3D 1H-MRSI), and 18FDG-PET enables an improved differentiation of benign and malignant breast tumors.Experimental Design: Seventy-six female patients (mean age, 55.7 years; range, 25–86 years) with an imaging abnormality (BI-RADS 0, 4–5) were included in this Institutional Review Board (IRB)-approved study. Patients underwent fused PET-MRI of the breast with 18FDG-PET/CT and MP MRI at 3T. The likelihood of malignancy was assessed for all single parameters, for MP MRI with two/three parameters, and for MP 18FDG PET-MRI. Histopathology was used as the standard of reference. Appropriate statistical tests were used to assess sensitivity, specificity, and diagnostic accuracy for each assessment combination.Results: There were 53 malignant and 23 benign breast lesions. MP 18FDG PET-MRI yielded a significantly higher area under the cure (AUC) of 0.935 than DCE-MRI (AUC, 0.86; P = 0.044) and the combination of DCE-MRI and another parameter (AUC, 0.761–0.826; P = 0.013–0.020). MP 18FDG PET-MRI showed slight further improvement to MP MRI with three parameters (AUC, 0.925; P = 0.317). Using MP 18FDG PET-MRI there would have been a reduction of the unnecessary breast biopsies recommended by MP imaging with one or two parameters (P = 0.002–0.011).Conclusion: This feasibility study shows that MP 18FDG PET-MRI enables an improved differentiation of benign and malignant breast tumors when several MRI and PET parameters are combined. MP 18FDG PET-MRI may lead to a reduction in unnecessary breast biopsies. Clin Cancer Res; 20(13); 3540–9. ©2014 AACR.