Supplementary Table S1 from Natural Killer Cell Activation by Ubiquitin-specific Protease 6 Mediates Tumor Suppression in Ewing Sarcoma

Jain, Kanika; Henrich, Ian C.; Quick, Laura; Young, Robert; Mondal, Shreya; Oliveira, Andre M.; Blobel, Gerd A.; Chou, Margaret M.

doi:10.1158/2767-9764.24008219.v1

crc-22-0505-s01.pdf (33.05 kB)

Supplementary Table S1 from Natural Killer Cell Activation by Ubiquitin-specific Protease 6 Mediates Tumor Suppression in Ewing Sarcoma

journal contribution

posted on 2023-08-22, 14:20 authored by Kanika Jain, Ian C. Henrich, Laura Quick, Robert Young, Shreya Mondal, Andre M. Oliveira, Gerd A. Blobel, Margaret M. Chou

Flow antibodies used

Funding

HHS | National Institutes of Health (NIH)

Sarcoma Foundation of America (SFA)

Kids Beating Cancer

State of Pennsylvania Department of Health

History

ARTICLE ABSTRACT

This study provides novel insights into the immunomodulatory functions of USP6, the only cancer cell–intrinsic factor demonstrated to regulate the immune TME in Ewing sarcoma. We demonstrate that USP6-mediated suppression of Ewing sarcoma tumorigenesis is dependent on NK cells. USP6 directly activates NK cell cytolytic function, inducing both intratumoral and systemic activation of NK cells in an Ewing sarcoma xenograft model.