American Association for Cancer Research
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Supplementary Table 6. from Associations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study

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posted on 2024-04-03, 07:20 authored by Hyung-Suk Yoon, Jie Wu, Chris Shidal, Yan Sun, Adrian A. Franke, Jae Jeong Yang, Dejana Braithwaite, Regina Courtney, Hui Cai, William J. Blot, Xiao-Ou Shu, Wei Zheng, Qiuyin Cai

Association between Plasma Tocopherols and Histological Subtype of Lung Cancer


National Cancer Institute (NCI)

United States Department of Health and Human Services

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National Institute on Minority Health and Health Disparities (NIMHD)

United States Department of Health and Human Services

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Despite the various anticancer activities of tocopherols, little is known about tocopherols associated with lung cancer risk among low-income African Americans (AA) and European Americans (EA) who are disproportionately affected by the disease. We conducted a nested case–control study that included 209 incident lung cancer cases and 406 matched controls within the Southern Community Cohort Study. Using biospecimens collected at cohort enrollment, plasma levels of α-, β/γ-, δ-, and total-tocopherols were measured by high-performance liquid chromatography with photodiode array detection. Conditional logistic regression was used to estimate ORs and 95% confidence intervals (CI) for lung cancer risk after adjusting for potential confounders. Stratified analyses were also conducted. Plasma levels of total-tocopherols were inversely associated with lung cancer risk overall [OR (95% CI) for the highest vs. lowest tertile = 0.51 (0.30–0.90)]. The inverse association remained significant among EAs [0.20 (0.06–0.65)], men [0.43 (0.21–0.90)], current smokers [0.49 (0.26–0.93)], and cases diagnosed within 2 years of blood draw [0.36 (0.15–0.86)], though we did not find a significant risk reduction among AAs [0.75 (0.39–1.45)]. Notably, we found significant interactions between α-tocopherol and race after controlling the FDR to correct for multiple comparisons (Pinteraction = 0.02). Our results indicate that plasma total-tocopherols are inversely associated with lung cancer risk, but the association may differ across specific isomeric forms of tocopherols, race, or other individuals’ characteristics. Further large-scale studies are warranted to confirm our findings. Recommendations on tocopherols for lung cancer prevention should take isomers, race, and smoking behaviors into consideration.

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