American Association for Cancer Research
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Supplementary Table 4 from Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort

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posted on 2023-03-30, 21:16 authored by Krasimira Aleksandrova, Heiner Boeing, Mazda Jenab, H. Bas Bueno-de-Mesquita, Eugene Jansen, Fränzel J. B. van Duijnhoven, Sabina Rinaldi, Veronika Fedirko, Isabelle Romieu, Elio Riboli, Marc J. Gunter, Sabine Westphal, Kim Overvad, Anne Tjønneland, Jytte Halkjær, Antoine Racine, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Rudolf Kaaks, Annekatrin Lukanova, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Amalia Mattiello, Valeria Pala, Domenico Palli, Rosario Tumino, Paolo Vineis, Genevieve Buckland, María-José Sánchez, Pilar Amiano, José María Huerta, Aurelio Barricarte, Virginia Menéndez, Petra H. Peeters, Stefan Söderberg, Richard Palmqvist, Naomi E. Allen, Francesca L. Crowe, Kay-Tee Khaw, Nickolas Wareham, Tobias Pischon

PDF file - 100K, Relative risks (RR-s) and 95% confidence intervals (CI-s) of colon, rectal and colorectal cancer according to sex-specific quintiles of baseline leptin concentrations, in men and women , the European Prospective Investigation into Cancer and Nutrition (EPIC), 1992-2003



Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129 incident CRC cases (713 colon, 416 rectal) were matched within risk sets to 1,129 controls. Conditional logistic regression was used to calculate relative risks (RR) and 95% confidence intervals (CI). After multivariable adjustment including body mass index (BMI), waist circumference, and baseline leptin concentrations, sOB-R was strongly inversely associated with CRC (RR comparing the highest quintile vs. the lowest, 0.55; 95% CI, 0.40–0.76; Ptrend = 0.0004) and colon cancer (RR, 0.42; 95% CI, 0.28–0.63, Ptrend = 0.0001); whereas no association was seen for rectal cancer (RR adjusted for BMI and waist circumference, 0.83; 95% CI, 0.48–1.44, Ptrend = 0.38). In contrast, leptin was not associated with risk of CRC (RR adjusted for BMI and waist circumference, 0.85; 95% CI, 0.56–1.29, Ptrend = 0.23). Additional adjustments for circulating metabolic biomarkers did not attenuate these results. These novel findings suggest a strong inverse association between circulating sOB-R and CRC risk, independent of obesity measures, leptin concentrations, and other metabolic biomarkers. Further research is needed to confirm the potentially important role of sOB-R in CRC pathogenesis. Cancer Res; 72(20); 5328–37. ©2012 AACR.

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