American Association for Cancer Research
10780432ccr122970-sup-tab3.pdf (60.62 kB)

Supplementary Table 3 from Genetic Profiling Identifies Two Classes of Soft-Tissue Leiomyosarcomas with Distinct Clinical Characteristics

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journal contribution
posted on 2023-03-31, 17:20 authored by Antoine Italiano, Pauline Lagarde, Céline Brulard, Philippe Terrier, Marick Laë, Bernard Marques, Dominique Ranchere-Vince, Jean-Jacques Michels, Martine Trassard, Angela Cioffi, Sophie Piperno-Neumann, Christine Chevreau, Jean-Yves Blay, Corinne Delcambre, Nicolas Isambert, Nicolas Penel, Jacques-Olivier Bay, Sylvie Bonvalot, Axel Le Cesne, Jean-Michel Coindre, Frédéric Chibon

PDF file - 60K, Biological pathways overrepresented in "ARM" and internal trunk LMS



Purpose: Data about the prognostic factors of soft-tissue leiomyosarcomas and their correlation with molecular profile are limited.Experimental Design: From 1990 to 2010, 586 adult patients with a primary soft-tissue leiomyosarcoma were included in the French Sarcoma Group (GSF) database after surgery of the primary tumor. Multivariate analyses were conducted by Cox regression model in a backward stepwise procedure. Genetic profiling was conducted for 73 cases.Results: Median age was 59 years (range, 21–98 years). The median follow-up of patients alive was 46 months. The 5-year metastasis-free survival (MFS) rate was 51% (95% location and grade > I were independent adverse prognostic factors for MFS). The 5-year overall survival (OS) rate was 63% [95% confidence interval (CI), 59–67]. On multivariate analysis, age ≥ 60 years old, tumor size > 5 cm, deep location, and grade > I were independent adverse prognostic factors for OS. Molecular profiling identified specific clusters with activation of different biologic pathways: retroperitoneal leiomyosarcomas are characterized by overexpression of genes involved in muscle differentiation and nonretroperitoneal leiomyosarcomas characterized by overexpression of genes mainly involved in extracellular matrix, wounding, and adhesion pathways. The CINSARC signature but not comparative genomic hybridization (CGH) profiling was predictive of outcome.Conclusion: Soft-tissue leiomyosarcomas represent a heterogeneous group of tumors with at least two categories, retroperitoneal and extremities leiomyosarcomas, having specific clinical outcome and molecular features. Future clinical trials should consider this heterogeneity for a better stratification of patients. Clin Cancer Res; 19(5); 1190–6. ©2013 AACR.