American Association for Cancer Research
crc-23-0193-s07.pdf (46.75 kB)

Supplementary Table 2 from Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs

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journal contribution
posted on 2023-08-25, 14:20 authored by Thomas S. Dexheimer, Nathan P. Coussens, Thomas Silvers, John Wright, Joel Morris, James H. Doroshow, Beverly A. Teicher

Table S2. Links to the PubChem assays.



Clinical efficacy of DNA-damaging anticancer drugs can be influenced by the DNA damage response in tumor cells. The potentiation of DNA-damaging drugs by pharmacologic modulation of DNA repair pathways was assessed in multicellular tumor spheroids. Although most combinations demonstrated additive cytotoxicity, synergistic cytotoxicity was observed for several drug combinations.