American Association for Cancer Research
00085472can124563-sup-supp_table_2.pdf (42.25 kB)

Supplementary Table 2 from BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages

Download (42.25 kB)
journal contribution
posted on 2023-03-30, 21:29 authored by Jae-Ho Lee, Geun Taek Lee, Seung Hyo Woo, Yun-Sok Ha, Seok Joo Kwon, Wun-Jae Kim, Isaac Yi Kim

Supplementary Table 2 - PDF 42K, Multivariate Cox Analysis for the three-marker signature



Dysregulated bone morphogenetic proteins (BMP) may contribute to the development and progression of renal cell carcinoma (RCC). Herein, we report that BMP-6 promotes the growth of RCC by interleukin (IL)-10–mediated M2 polarization of tumor-associated macrophages (TAM). BMP-6–mediated IL-10 expression in macrophages required Smad5 and STAT3. In human RCC specimens, the three-marker signature BMP-6/IL-10/CD68 was associated with a poor prognosis. Furthermore, patients with elevated IL-10 serum levels had worse outcome after surgery. Together, our results suggest that BMP-6/macrophage/IL-10 regulates M2 polarization of TAMs in RCC. Cancer Res; 73(12); 3604–14. ©2013 AACR.