American Association for Cancer Research
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Supplementary Table 1 from No Association between Ovarian Cancer Susceptibility Variants and Breast Cancer Risk among Chinese Women

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journal contribution
posted on 2023-03-31, 13:42 authored by Xiangyu Ma, Qiuyin Cai, Ryan J. Delahanty, Xiao-Ou Shu, Ben Zhang, Wei Lu, Yu-Tang Gao, Wei Zheng, Jirong Long, Alicia Beeghly-Fadiel

PDF file - 79K, Supplemental Table 1. Ovarian Cancer Susceptibility Variants and Breast Cancer Risk among Chinese Women



Background: As breast and ovarian cancers may have similar etiologies, this study aimed to evaluate the hypothesis that breast cancer shares common genetic susceptibility variants with ovarian cancer.Methods: Ten genetic variants in nine loci were previously identified to be associated with ovarian cancer risk among Caucasian women; an additional 353 variants in high-linkage disequilibrium (r2 ≥ 0.6) among Han Chinese were identified. Data were available from the Affymetrix Genome-Wide Array (6.0) or MACH imputation for 25 and 78 common genetic variants [minor allele frequency (MAF) ≥0.05], respectively. Associations with breast cancer risk were evaluated by additive logistic regression models among 2,918 breast cancer cases and 2,324 controls.Results: No associations with breast cancer risk were evident for 103 ovarian cancer susceptibility variants in five loci. Four loci were not evaluated, as they included only rare variants (MAF < 0.05).Conclusions: Ovarian cancer susceptibility variants identified in Caucasian women were not associated with breast cancer risk among 5,242 Chinese women.Impact: These findings suggest that breast and ovarian cancer may not share common susceptibility variants among Chinese women. Cancer Epidemiol Biomarkers Prev; 22(3); 467–9. ©2013 AACR.

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