American Association for Cancer Research
Browse
00085472can100190-sup-stab_1.pdf (15.46 kB)

Supplementary Table 1 from Integrated Profiling Reveals a Global Correlation between Epigenetic and Genetic Alterations in Mesothelioma

Download (15.46 kB)
journal contribution
posted on 2023-03-30, 19:48 authored by Brock C. Christensen, E. Andres Houseman, Graham M. Poage, John J. Godleski, Raphael Bueno, David J. Sugarbaker, John K. Wiencke, Heather H. Nelson, Carmen J. Marsit, Karl T. Kelsey
Supplementary Table 1 from Integrated Profiling Reveals a Global Correlation between Epigenetic and Genetic Alterations in Mesothelioma

History

ARTICLE ABSTRACT

Development of mesothelioma is linked mainly to asbestos exposure, but the combined contributions of genetic and epigenetic alterations are unclear. We investigated the potential relationships between gene copy number (CN) alterations and DNA methylation profiles in a case series of pleural mesotheliomas (n = 23). There were no instances of significantly correlated CN alteration and methylation at probed loci, whereas averaging loci over their associated genes revealed only two genes with significantly correlated CN and methylation alterations. In contrast to the lack of discrete correlations, the overall extent of tumor CN alteration was significantly associated with DNA methylation profile when comparing CN alteration extent among methylation profile classes. Further, there was evidence that this association was partially attributable to prevalent allele loss at the DNA methyltransferase gene DNMT1. Our findings define a strong association between global genetic and global epigenetic dysregulation in mesothelioma, rather than a discrete, local coordination of gene inactivation. Cancer Res; 70(14); 5686–94. ©2010 AACR.

Usage metrics

    Cancer Research

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC