Supplementary Table 1 from BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages

Lee, Jae-Ho; Lee, Geun Taek; Woo, Seung Hyo; Ha, Yun-Sok; Kwon, Seok Joo; Kim, Wun-Jae; Kim, Isaac Yi

doi:10.1158/0008-5472.22395053.v1

Supplementary Table 1 from BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages

journal contribution

posted on 2023-03-30, 21:29 authored by Jae-Ho Lee, Geun Taek Lee, Seung Hyo Woo, Yun-Sok Ha, Seok Joo Kwon, Wun-Jae Kim, Isaac Yi Kim

Supplementary Table 1 - PDF file 56K, PCR primer sequences

History

ARTICLE ABSTRACT

Dysregulated bone morphogenetic proteins (BMP) may contribute to the development and progression of renal cell carcinoma (RCC). Herein, we report that BMP-6 promotes the growth of RCC by interleukin (IL)-10–mediated M2 polarization of tumor-associated macrophages (TAM). BMP-6–mediated IL-10 expression in macrophages required Smad5 and STAT3. In human RCC specimens, the three-marker signature BMP-6/IL-10/CD68 was associated with a poor prognosis. Furthermore, patients with elevated IL-10 serum levels had worse outcome after surgery. Together, our results suggest that BMP-6/macrophage/IL-10 regulates M2 polarization of TAMs in RCC. Cancer Res; 73(12); 3604–14. ©2013 AACR.