American Association for Cancer Research
epi-23-0056_supplementary_table_1_suppst1.docx (26.71 kB)

Supplementary Table 1 from Association between Sleep Duration and Colorectal Adenomas: Findings from a Case–Control Study in Vietnam

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posted on 2023-07-12, 14:00 authored by Chi Thi-Du Tran, Pedram Paragomi, Mo Thi Tran, Mai Vu-Tuyet Nguyen, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Thi-Thu Ha, Nam Chi Bui, Hien Huy Vu, Phuong Que Ta, Martha J. Shrubsole, Qiuyin Cai, Fei Ye, Song Huu Le, Khien Van Vu, Huong Thi-Thanh Tran, Thuan Van Tran, Paolo Boffetta, Xiao-Ou Shu, Hung N. Luu

This supplementary table describes the distributions of baseline characteristics among study participants by cases versus controls



Colorectal cancer is one of the leading cancers worldwide and in Vietnam. Adenomas are important precursors of colorectal cancer. Study on the association between sleep duration and development of colorectal adenoma (CRA) is limited, particularly among Vietnamese population. We conducted an individually matched case–control study of 870 CRA cases and 870 controls in a large-scale colorectal screening program involving 103,542 individuals ages ≥40 years old in Hanoi, Vietnam. Sleep duration was categorized in three groups: short: ≤6 hours/day, normal: 7 to 8 hours/day, and long: >8 hours/day. Conditional logistic regression was used to evaluate the association between sleep duration and adenomas risk after controlling for potential confounders. Overall, short-sleep duration was associated with increased risk of having CRA compared with normal duration [OR, 1.48; 95% confidence interval (CI), 1.12–1.97]. This pattern was present in both females (OR, 1.58; 95% CI, 1.14–2.18) and males (OR, 1.45; 95% CI, 1.08–1.93), with advanced adenomas (OR, 1.61; 95% CI, 1.09–2.38) and non-advanced adenomas (OR, 1.66; 95% CI, 1.19–2.32). Furthermore, the association between CRA development and short-sleep duration was more apparent among females who were nondrinker, nonobese, physically active, with proximal or both sided adenomas and with cardiometabolic disorder. Among males, the short-sleep duration was associated with CRA risk among never-smoking, cardiometabolic disorders, and obese. Short-sleep duration was associated with increased prevalence of both advanced and non-advanced CRAs among Vietnamese population. Findings from this study showed that maintaining an adequate sleep duration may have an important implication for colorectal adenoma prevention and control.

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