American Association for Cancer Research
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Supplementary Table 1 from A Mendelian Randomization Analysis of 55 Genetically Predicted Metabolic Traits with Breast Cancer Survival Outcomes in the Pathways Study

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posted on 2023-06-22, 14:20 authored by Peter N. Fiorica, Haiyang Sheng, Qianqian Zhu, Janise M. Roh, Cecile A. Laurent, Isaac J. Ergas, Jennifer Delmerico, Marilyn L. Kwan, Lawrence H. Kushi, Christine B. Ambrosone, Song Yao

Polygenic score models pulled from the polygenic score catalog

Funding

HHS | NIH | National Cancer Institute (NCI)

HHS | National Institutes of Health (NIH)

Breast Cancer Research Foundation (BCRF)

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ARTICLE ABSTRACT

To our knowledge, this is the largest study of PGS for metabolic traits with breast cancer prognosis. The findings revealed significant associations of PGS for cardiovascular disease, hypertension, and cystatin C levels with several breast cancer survival outcomes. These findings implicate an underappreciated role of metabolic traits in breast cancer prognosis that would warrant further exploration.

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    Cancer Research Communications

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    Keywords

    Genetics Of Cancer Risk & OutcomeSurvivorship ResearchEpidemiology of survivorshipEndogenous Risk FactorsObesityCancer InterceptionBiomarkers and interventionBreast CancerMetabolismEpidemiology

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    CC BY

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