Supplementary Table 1 from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

Berta, Giovanni N.; Sprio, Andrea E.; Iezzi, Manuela; Spadaro, Michela; Cappia, Susanna; Salamone, Paolina; Di Scipio, Federica; Mognetti, Barbara; Papotti, Mauro; Musiani, Piero; Forni, Guido; Cavallo, Federica

doi:10.1158/1940-6207.22525079.v1

19406207capr100301-sup-0301_supp_table.pdf (53.8 kB)

Supplementary Table 1 from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

journal contribution

posted on 2023-04-03, 19:28 authored by Giovanni N. Berta, Andrea E. Sprio, Manuela Iezzi, Michela Spadaro, Susanna Cappia, Paolina Salamone, Federica Di Scipio, Barbara Mognetti, Mauro Papotti, Piero Musiani, Guido Forni, Federica Cavallo

Supplementary Table 1 from A DNA Vaccine against ERBB2 Impairs Chemical Carcinogenesis in Random-Bred Hamsters

History

ARTICLE ABSTRACT

Vaccines against oncoantigens halt early neoplastic lesions in several cancer-prone, genetically engineered mouse models, whereas their ability to prevent chemical carcinogenesis has not been explored. This is a significant issue, as exposure to chemical mutagens is responsible for a substantial percentage of cancers worldwide. Here, we show that the archetypal oncoantigen ERBB2 is transiently overexpressed in Syrian hamsters during the early stages of 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral carcinogenesis. Repeated DNA vaccinations against ERBB2 significantly reduce the number, size, and severity of oral lesions in a manner directly proportional to the anti-ERBB2 antibody response. These results support the prospects of vaccines as a fresh strategy in the management of individuals at risk for exposure to defined carcinogenic agents. Cancer Prev Res; 4(7); 994–1001. ©2011 AACR.