Supplementary Table 1, Figures 1-5 from Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells

Martin-Orozco, Natalia; Li, Yufeng; Wang, Yijun; Liu, Shijuan; Hwu, Patrick; Liu, Yong-Jun; Dong, Chen; Radvanyi, Laszlo

doi:10.1158/0008-5472.22384269.v1

00085472can101379-sup-can_12-1-10_martin-orozco.pdf (152.49 kB)

Supplementary Table 1, Figures 1-5 from Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells

journal contribution

posted on 2023-03-30, 19:44 authored by Natalia Martin-Orozco, Yufeng Li, Yijun Wang, Shijuan Liu, Patrick Hwu, Yong-Jun Liu, Chen Dong, Laszlo Radvanyi

Supplementary Table 1, Figures 1-5 from Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells

History

ARTICLE ABSTRACT

CD4+CD25+Foxp3+ T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion. Cancer Res; 70(23); 9581–90. ©2010 AACR.