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Supplementary Table 1, Figures 1-5 from Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells

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posted on 2023-03-30, 19:44 authored by Natalia Martin-Orozco, Yufeng Li, Yijun Wang, Shijuan Liu, Patrick Hwu, Yong-Jun Liu, Chen Dong, Laszlo Radvanyi
Supplementary Table 1, Figures 1-5 from Melanoma Cells Express ICOS Ligand to Promote the Activation and Expansion of T-Regulatory Cells

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ARTICLE ABSTRACT

CD4+CD25+Foxp3+ T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion. Cancer Res; 70(23); 9581–90. ©2010 AACR.

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