Supplementary Report from PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway

Wang, Xue; Lee, Derrick; Xu, Haibo; Sui, Yuan; Meisenhelder, Jill; Hunter, Tony

doi:10.1158/2159-8290.28522982

Supplementary Report from PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway

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posted on 2025-03-03, 08:21 authored by Xue Wang, Derrick Lee, Haibo Xu, Yuan Sui, Jill Meisenhelder, Tony Hunter

Supplementary report addressing the cell line authentication and Mycoplasma testing

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Division of Cancer Prevention, National Cancer Institute (DCP, NCI)

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ARTICLE ABSTRACT

This study provides deeper insights into the regulatory role of the phospho–dependent prolyl isomerase PIN1 in bladder cancer. The identification of the link between PIN1 and SREBP2-mediated transcription and cholesterol biosynthesis offers the potential for developing novel therapeutic strategies for bladder cancer.

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Biochemistry Protein/protein interactions Cancer Prevention Animal models of prevention Carcinogenesis Tumor initiation and promotion Cell Signaling Drug Targets Genitourinary Cancers Bladder cancer Metabolism Metabolic pathways

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Supplementary Report from PIN1 Prolyl Isomerase Promotes Initiation and Progression of Bladder Cancer through the SREBP2-Mediated Cholesterol Biosynthesis Pathway

Funding

Division of Cancer Prevention, National Cancer Institute (DCP, NCI)

History

ARTICLE ABSTRACT

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