Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

Devy, Laetitia; Huang, Lili; Naa, Laurent; Yanamandra, Niranjan; Pieters, Henk; Frans, Nicolas; Chang, Edward; Tao, Qingfeng; Vanhove, Marc; Lejeune, Annabelle; van Gool, Reinoud; Sexton, Daniel J.; Kuang, Guannan; Rank, Douglas; Hogan, Shannon; Pazmany, Csaba; Ma, Yu Lu; Schoonbroodt, Sonia; Nixon, Andrew E.; Ladner, Robert C.; Hoet, Rene; Henderikx, Paula; TenHoor, Chris; Rabbani, Shafaat A.; Valentino, Maria Luisa; Wood, Clive R.; Dransfield, Daniel T.

doi:10.1158/0008-5472.22381518.v1

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

https://doi.org/10.1158/0008-5472.22381518

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posted on 2023-03-30, 19:14 authored by Laetitia Devy, Lili Huang, Laurent Naa, Niranjan Yanamandra, Henk Pieters, Nicolas Frans, Edward Chang, Qingfeng Tao, Marc Vanhove, Annabelle Lejeune, Reinoud van Gool, Daniel J. Sexton, Guannan Kuang, Douglas Rank, Shannon Hogan, Csaba Pazmany, Yu Lu Ma, Sonia Schoonbroodt, Andrew E. Nixon, Robert C. Ladner, Rene Hoet, Paula Henderikx, Chris TenHoor, Shafaat A. Rabbani, Maria Luisa Valentino, Clive R. Wood, Daniel T. Dransfield

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

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DOI - Is supplement to Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

ARTICLE ABSTRACT

Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization. Besides cleaving matrix proteins, MMP-14 activates proMMP-2 leading to an amplification of pericellular proteolytic activity. To examine the contribution of MMP-14 to tumor growth and angiogenesis, we used DX-2400, a highly selective fully human MMP-14 inhibitory antibody discovered using phage display technology. DX-2400 blocked proMMP-2 processing on tumor and endothelial cells, inhibited angiogenesis, and slowed tumor progression and formation of metastatic lesions. The combination of potency, selectivity, and robust in vivo activity shows the potential of a selective MMP-14 inhibitor for the treatment of solid tumors. [Cancer Res 2009;69(4):1517–26]

Supplementary Methods and Materials from Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

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