Supplementary Methods and Figures from NUP98–PHF23 Is a Chromatin-Modifying Oncoprotein That Causes a Wide Array of Leukemias Sensitive to Inhibition of PHD Histone Reader Function
posted on 2023-04-03, 20:46authored bySheryl M. Gough, Fan Lee, Fan Yang, Robert L. Walker, Yeulin J. Zhu, Marbin Pineda, Masahiro Onozawa, Yang Jo Chung, Sven Bilke, Elise K. Wagner, John M. Denu, Yi Ning, Bowen Xu, Gang Greg Wang, Paul S. Meltzer, Peter D. Aplan
PDF file 601K, Supplementary Methods. Figure S1. The NUP98-PHF23 (NP23) transgene and peripheral blood (PB) characteristics of NP23 mice. Figure S2. NP23 AML and pre-T LBL. Figure S3. NP23 bi-clonal AML/pre-T LBL, B-ALL and erythroid leukemias. Figure S4.Impaired hematopoietic development in NP23 progenitor cell populations. Figure S5. Validation of differential gene expression in NP23 tissues. Figure S6. NP23 cells are sensitive to disulfiram, an inhibitor of PHD domain H3K4me3 binding