Supplementary Methods, Figure Legends, Tables S1, S3 - S6 from Intratumoral Heterogeneity in a <i>Trp53</i>-Null Mouse Model of Human Breast Cancer

<p>Supplementary Table S1. Partial list of probes preferentially expressed in the Lin-CD29HCD24L cells. Supplementary Table S3. Co-transplantation of increasing numbers of niche cells resulted in increasing numbers of tumors. Supplementary Table S4. a. Pairwise comparisons using fixed number of niche cells displayed a reduced tumor latency with increasing numbers of TICs. b. Pairwise comparisons using 10 TICs demonstrated that tumor formation was more rapid with 10 niche cells as compared to 0. c. Pairwise comparisons using 20 TICs demonstrated that tumor formation was faster with 10 niche cells as compared to 0. Supplementary Table S5. Different types of niche cells were associated with different tumor forming frequencies. Supplementary Table S6. a. No difference observed between shRNA groups for 0 niche cell relative to the control shRNA. b. No difference observed between shRNA groups for 2 niche cells relative to the control shRNA. c. A marginal difference for 10 niche cells relative to the control shRNA. d. A significant difference for 20 niche cells as relative to the control shRNA.</p>