American Association for Cancer Research
10559965epi100698-sup-epi-10-0698_rebbeck_supp_mat.pdf (274.92 kB)

Supplementary Materials from Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent

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posted on 2023-03-31, 13:20 authored by Bao-Li Chang, Elaine Spangler, Stephen Gallagher, Christopher A. Haiman, Brian Henderson, William Isaacs, Marnita L. Benford, LaCreis R. Kidd, Kathleen Cooney, Sara Strom, Sue Ann Ingles, Mariana C. Stern, Roman Corral, Amit D. Joshi, Jianfeng Xu, Veda N. Giri, Benjamin Rybicki, Christine Neslund-Dudas, Adam S. Kibel, Ian M. Thompson, Robin J. Leach, Elaine A. Ostrander, Janet L. Stanford, John Witte, Graham Casey, Rosalind Eeles, Ann W. Hsing, Stephen Chanock, Jennifer J. Hu, Esther M. John, Jong Park, Klara Stefflova, Charnita Zeigler-Johnson, Timothy R. Rebbeck
Supplementary Materials from Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent



Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent.Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci.Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2.Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.Impact: The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent. Cancer Epidemiol Biomarkers Prev; 20(1); 23–32. ©2011 AACR.

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