Supplementary Materials and Methods from Antigen Shedding May Improve Efficiencies for Delivery of Antibody-Based Anticancer Agents in Solid Tumors

Pak, Youngshang; Zhang, Yujian; Pastan, Ira; Lee, Byungkook

doi:10.1158/0008-5472.22393433.v1

00085472can113925-sup-mm__208k.pdf (208.11 kB)

Supplementary Materials and Methods from Antigen Shedding May Improve Efficiencies for Delivery of Antibody-Based Anticancer Agents in Solid Tumors

journal contribution

posted on 2023-03-30, 21:14 authored by Youngshang Pak, Yujian Zhang, Ira Pastan, Byungkook Lee

PDF file - 208K, Contains all equations of the model and their derivations

History

ARTICLE ABSTRACT

Recombinant immunotoxins (RIT) are targeted anticancer agents that are composed of a targeting antibody fragment and a protein toxin fragment. SS1P is a RIT that targets mesothelin on the surface of cancer cells and is being evaluated in patients with mesothelioma. Mesothelin, like many other target antigens, is shed from the cell surface. However, whether antigen shedding positively or negatively affects the delivery of RIT remains unknown. In this study, we used experimental data with SS1P to develop a mathematical model that describes the relationship between tumor volume changes and the dose level of the administered RIT, while accounting for the potential effects of antigen shedding. Cancer Res; 72(13); 3143–52. ©2012 AACR.