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Supplementary Materials and Methods from A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer

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posted on 2023-06-23, 17:40 authored by Niccolò Roda, Andrea Cossa, Roman Hillje, Andrea Tirelli, Federica Ruscitto, Stefano Cheloni, Chiara Priami, Alberto Dalmasso, Valentina Gambino, Giada Blandano, Andrea Polazzi, Paolo Falvo, Elena Gatti, Luca Mazzarella, Lucilla Luzi, Enrica Migliaccio, Pier Giuseppe Pelicci

Supplementary Materials and Methods, including a deeper characterisation of the Methods outlined in the Main manuscript and the description of additional analyses not included in the main text

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ARTICLE ABSTRACT

Transcriptional lineage tracing coupled with single-cell transcriptomics defined the transcriptional programs underlying metastatic progression in breast cancer, identifying prognostic signatures and prevention strategies.

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