Supplementary Materials and Methods, Supplementary Figures 1 through 8 with legends, and Supplementary Tables 1 to 5 from ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells

The supplementary data contain Supplementary Materials and Methods, Supplementary Figures 1 through 8 with legends, and Supplementary Tables 1 to 5. Supplementary Fig. 1. YW3-56 inhibits growth of p53 wild type and mutant cells. Supplementary Fig. 2. PAD inhibitor YW3-56 inhibits PAD4 in HL-60 derived granulocytic cells. Supplementary Fig. 3. Effects of YW3-56 on the ATF4 and AMPK gene networks. Supplementary Fig. 4. ATF4 directly binds to the SESN2 and DDIT4 promoters. Supplementary Fig. 5. ChIP-exo analyses of ATF4 binding to its target sites. Supplementary Figure 6. mTOR inhibition following thapsigargin induced ER stress. Supplementary Figure 7. Effects of ATF4, SESN2, and DDIT4 depletion on cell growth and YW3-56 mediated cell killing. Supplementary Figure 8. Features of YW3-56 induced cell death. Supplementary Table 1. List of qRT-PCR and ChIP-qPCR primers used in this research work. Supplementary Table 2. Genes with altered expression after YW3-56 treatment. (see Excel spreadsheet) Supplementary Table 3. List of ATF4 associated genes. (see Excel spreadsheet) Supplementary Table 4. List of CEBPB associated genes. (see Excel spreadsheet) Supplementary Table 5. Expression changes of ATF4 and CEBPB candidate genes after YW3-56 treatment.