crc-21-0019-s01.pdf (11.43 MB)
Supplementary Materials and Methods, Figures 1-6 from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
journal contribution
posted on 2023-04-04, 01:21 authored by Alina Castell, Qinzi Yan, Karin Fawkner, Wesam Bazzar, Fan Zhang, Malin Wickström, Mohammad Alzrigat, Marcela Franco, Cecilia Krona, Donald P. Cameron, Cecilia Dyberg, Thale Kristin Olsen, Vasiliki Verschut, Linnéa Schmidt, Sheryl Y. Lim, Loay Mahmoud, Per Hydbring, Sören Lehmann, Laura Baranello, Sven Nelander, John Inge Johnsen, Lars-Gunnar LarssonSupplementary Figure 1. MYCMI-7 selectively inhibits the MYC:MAX interaction in cells and blocks MYC's association with chromatin. Supplementary Figure 2. MYCMI-7 downregulates MYC and MYCN protein expression. Supplementary Figure 3. MYCMI-7 reduces tumor cell growth/viability of MYC-driven tumor cells and inhibits oncogenic transformation in 2D and 3D cultures. Supplementary Figure 4. Effects of MYCMI-7 is relation to TOP2A activity in vitro and in cells. Supplementary Figure 5. Treatment of MYC/BCL-XL-driven acute myeloid leukemia with MYCMI-7. Supplementary Figure 6. MYCMI-7 inhibits growth of MDA-MB-231 breast cancer cell and SK-N-DZ MYCN-amplified neuroblastoma cell xenografts in vivo.