Supplementary Material S8 from Diagnostic Accuracy of Blood-based Biomarkers for Pancreatic Cancer: A Systematic Review and Meta-analysis

Kane, Laura E.; Mellotte, Gregory S.; Mylod, Eimear; O'Brien, Rebecca M.; O'Connell, Fiona; Buckley, Croí E.; Arlow, Jennifer; Nguyen, Khanh; Mockler, David; Meade, Aidan D.; Ryan, Barbara M.; Maher, Stephen G.

doi:10.1158/2767-9764.22545266.v1

Supplementary Material S8 from Diagnostic Accuracy of Blood-based Biomarkers for Pancreatic Cancer: A Systematic Review and Meta-analysis

journal contribution

posted on 2023-04-04, 01:42 authored by Laura E. Kane, Gregory S. Mellotte, Eimear Mylod, Rebecca M. O'Brien, Fiona O'Connell, Croí E. Buckley, Jennifer Arlow, Khanh Nguyen, David Mockler, Aidan D. Meade, Barbara M. Ryan, Stephen G. Maher

Figure S8 panels A-E

Funding

Meath Foundation

History

ARTICLE ABSTRACT

In a systematic review and three-level multivariate meta-analysis, it is shown for the first time that blood-based multi-biomarker panels for the diagnosis of PDAC exhibit superior performance in comparison with single biomarkers. CA19-9 is demonstrated to have limited utility alone, and to perform poorly in patient control cohorts of both healthy and benign individuals. Multi-biomarker panels containing CA19-9 produce the best diagnostic performance overall.