Supplementary Information from In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer

Supplementary Information. Supplementary Methods Supplementary Figures 1-6. Supp Fig. 1: Identification of bladder tumors by Computerized tomography (CT). Supp Fig 2: Determination of effective elimination of pRb and p130 in bladder tumors. Supp Fig 3: Expression of E2F1, E2F2 and E2F3a genes in mouse bladder tumors. Supp Fig 4: Polycomb-bound genes associate with early recurrence in external datasets of bladder cancer. Supp Fig. 5: Expression of SUZ12 and EED genes in human NMIBC. Supp Fig 6: Expression of E2F1, 2 and 3b genes in human NMIBC. Supplementary Tables 1, 7, 8, 9, 13 and 14. Supp Table 1: Sequence of the Oligonucleotides used in PCR analysis. Supp Table 7: Gene Set Enrichment Analysis of the deregulated genes in mouse bladder tumors. Supp Table 8: Overlap between the downregulated genes in mouse bladder tumors and human bladder cancer datasets from Oncomine database. Supp Table 9: Overlap between the upregulated genes in mouse bladder tumors and human bladder dataset from Oncomine database. Supp Table 13: Gene Set Enrichment Analysis of the deregulated genes in human recurrent bladder tumors. Supp Table 14: Overlap between the upregulated genes in our series of human recurrent bladder tumors and human bladder cancer datasets from Oncomine database. Supplementary References