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Supplementary Information from Nuclear Factor-κB, an Unappreciated Tumor Suppressor

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posted on 2023-03-30, 17:49 authored by Fei Chen, Vince Castranova
Supplementary Information from Nuclear Factor-κB, an Unappreciated Tumor Suppressor

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ARTICLE ABSTRACT

The notion that nuclear factor-κB (NF-κB) is a tumor-promoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-κB in carcinogenesis and tumorigenesis. Although the tumor suppressor–like effect of NF-κB remains to be rigorously established by further studies using cellular and animal models, these latest findings warrant caution with respect to blockage of NF-κB activation as a broad strategy in treating cancers. [Cancer Res 2007;67(23):11093–8]

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