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Supplementary Figures from The Germline and Somatic Origins of Prostate Cancer Heterogeneity

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journal contribution
posted on 2025-05-02, 07:24 authored by Takafumi N. Yamaguchi, Kathleen E. Houlahan, Helen Zhu, Natalie Kurganovs, Julie Livingstone, Natalie S. Fox, Jiapei Yuan, Jocelyn Sietsma Penington, Chol-Hee Jung, Tommer Schwarz, Weerachai Jaratlerdsiri, Job van Riet, Peter Georgeson, Stefano Mangiola, Kodi Taraszka, Robert Lesurf, Jue Jiang, Ken Chow, Lawrence E. Heisler, Yu-Jia Shiah, Susmita G. Ramanand, Michael J. Clarkson, Anne Nguyen, Shadrielle Melijah G. Espiritu, Ryan Stuchbery, Richard Jovelin, Vincent Huang, Connor Bell, Edward O’Connor, Patrick J. McCoy, Christopher M. Lalansingh, Marek Cmero, Adriana Salcedo, Eva K.F. Chan, Lydia Y. Liu, Phillip D. Stricker, Vinayak Bhandari, Riana M.S. Bornman, Dorota H.S. Sendorek, Andrew Lonie, Stephenie D. Prokopec, Michael Fraser, Justin S. Peters, Adrien Foucal, Shingai B.A. Mutambirwa, Lachlan Mcintosh, Michèle Orain, Matthew Wakefield, Valérie Picard, Daniel J. Park, Hélène Hovington, Michael Kerger, Alain Bergeron, Veronica Sabelnykova, Ji-Heui Seo, Mark M. Pomerantz, Noah Zaitlen, Sebastian M. Waszak, Alexander Gusev, Louis Lacombe, Yves Fradet, Andrew Ryan, Amar U. Kishan, Martijn P. Lolkema, Joachim Weischenfeldt, Bernard Têtu, Anthony J. Costello, Vanessa M. Hayes, Rayjean J. Hung, Housheng H. He, John D. McPherson, Bogdan Pasaniuc, Theodorus van der Kwast, Anthony T. Papenfuss, Matthew L. Freedman, Bernard J. Pope, Robert G. Bristow, Ram S. Mani, Niall M. Corcoran, Jüri Reimand, Christopher M. Hovens, Paul C. Boutros

Supplementary Figures & Figure Legends. Supplementary Figure 1 | Cohort Structure and Analysis. Supplementary Figure 2 | CNA Evolution & Transcriptomic Effects. Supplementary Figure 3 | Properties of Driver Mutations. Supplementary Figure 4 | Pathway & Signature Analysis of Driver Genes. Supplementary Figure 5 | Patterns of Mutational Drivers. Supplementary Figure 6 | Molecular Correlates of Clinical Behavior. Supplementary Figure 7 | Heterogeneity of Driver-Clinical Associations. Supplementary Figure 8 | Cohort Characteristics and Risk dQTL Replication. Supplementary Figure 9 | Local dQTLs Discovery. Supplementary Figure 10 | Replication of dQTLs. Supplementary Figure 11 | Enrichment of Sub-threshold dQTLs. Supplementary Figure 12 | Molecular Characterization of dQTLs. Supplementary Figure 13 | Association of dQTL Risk SNPs with eQTL and IMS. Supplementary Figure 14 | Clinical Characterization of dQTLs.

Funding

National Cancer Institute (NCI)

United States Department of Health and Human Services

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DOD Prostate Cancer Research Program (PCRP)

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ARTICLE ABSTRACT

This study uncovered 223 recurrently mutated driver regions using the largest cohort of prostate tumors to date. It reveals associations between germline SNPs, somatic drivers, and tumor aggression, offering significant insights into how prostate tumor evolution is shaped by germline factors and the timing of somatic mutations.