Supplementary Figures from Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Supplementary Figures 1-7 and Supplementary Table 1. Supplementary Figure 1 H&E stain and trichrome stain of representative 7-week-old KIC tumor tissue. Supplementary Figure 2 Axl gene expression in pancreatic cancer patient-derived xenografts. Supplementary Figure 3 Immunofluorescence of cleaved-caspase 3, p-histon-3, endomucin and EMT markers in Pan02 tumor tissue. Supplementary Figure 4 Western blot of TBK1/NF-κB signaling in tumor lysates from KIC mice treated with/without BGB324. Supplementary Figure 5 F4/80 stain in tumor tissue from KIC mice treated with BGB324 +/- gemcitabine. Supplementary Figure 6 Arginase 1 mRNA expression level in bone marrow-derived macrophages treated with IL-4 +/- BGB324. Supplementary Figure 7 Flow cytometry of KPC-M09 subcutaneous tumors treated with/without BGB324. Supplementary Table 1 Cytokine/Chemokine Concentration in KIC tumor lysates from different treatment groups.