Supplementary Figures from Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint

Supplementary Figure S1 APOBEC3B outlier expression is rare in AML. Supplementary FIgure S2. Checkpoint activation depends on the deaminase activity of A3A. Supplementary Figure S3. RPA foci accumulate upon A3A expression. Supplementary Figure S4. ATR is activated by A3A expression in different leukemia phenotypes. Supplementary Figure S5. Genetic abrogation of ATM does not impact survival of cells with high A3A expression. Supplementary Figure S6. Cell cycle arrest caused by A3A is abrogated by replication checkpoint inhibitors.