American Association for Cancer Research
crc-22-0124-s01.pdf (16.43 MB)

Supplementary Figures and Tables 1-2 from Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors

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journal contribution
posted on 2023-04-04, 01:23 authored by Joshy George, Yaohui Chen, Nourhan Abdelfattah, Keiko Yamamoto, Thomas D. Gallup, Scott I. Adamson, Brad Rybinski, Anuj Srivastava, Parveen Kumar, Min Gyu Lee, David S. Baskin, Wen Jiang, Jong Min Choi, William Flavahan, Jeffrey H. Chuang, Betty Y.S. Kim, Jiaqiong Xu, Sung Yun Jung, Kyuson Yun

Supplementary figures and Tables 1 & 2


DOD | US Army | MEDCOM | CDMRP | DOD Peer Reviewed Cancer Research Program (PRCRP)

Cancer Prevention and Research Institute of Texas (CPRIT)

HHS | NIH | NCI | National Cancer Institute (NCI)

HHS | NIH | National Cancer Institute (NCI)



The mechanism by which individual tumors become resistant to targeted therapies is thought to be unpredictable. This study provides novel insights into how selective pressure on cancer stem versus bulk tumor cells drives distinct and predictable mechanisms of resistance to targeted therapies. This finding paves a way for future treatment strategies that incorporate anticipated resistance mechanisms in devising second-line therapies in a personalized manner.