American Association for Cancer Research
Browse

Supplementary Figures and Tables 1-2 from Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors

Download (16.43 MB)
journal contribution
posted on 2023-04-04, 01:23 authored by Joshy George, Yaohui Chen, Nourhan Abdelfattah, Keiko Yamamoto, Thomas D. Gallup, Scott I. Adamson, Brad Rybinski, Anuj Srivastava, Parveen Kumar, Min Gyu Lee, David S. Baskin, Wen Jiang, Jong Min Choi, William Flavahan, Jeffrey H. Chuang, Betty Y.S. Kim, Jiaqiong Xu, Sung Yun Jung, Kyuson Yun

Supplementary figures and Tables 1 & 2

Funding

DOD | US Army | MEDCOM | CDMRP | DOD Peer Reviewed Cancer Research Program (PRCRP)

Cancer Prevention and Research Institute of Texas (CPRIT)

HHS | NIH | NCI | National Cancer Institute (NCI)

HHS | NIH | National Cancer Institute (NCI)

History

ARTICLE ABSTRACT

The mechanism by which individual tumors become resistant to targeted therapies is thought to be unpredictable. This study provides novel insights into how selective pressure on cancer stem versus bulk tumor cells drives distinct and predictable mechanisms of resistance to targeted therapies. This finding paves a way for future treatment strategies that incorporate anticipated resistance mechanisms in devising second-line therapies in a personalized manner.

Usage metrics

    Cancer Research Communications

    Categories

    Keywords

    Drug ResistanceNovel mechanismsRegulation of gene expression in drug resistanceStem Cell BiologyCancer stem cellsSmall Molecule AgentsCNS Cancers

    Licence

    CC BY

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC